Table 2.
Summary hematology values change, and stress indicators result in an elephant (E5) that developed clinical signs of EEHV-HD and died during the study period.
| Parameters | Study Means | 18 December 2018 | 9 January 2019 | 8 February 2019 | 8 March 2019 | 6 April 2019 | 6 May 2019 | 4 June 2019 | 16 June 2019 | 17 June 2019 | 18 June 2019 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Viral load (vgc/mL) | - | Undetected | Undetected | Undetected | Undetected | Undetected | Undetected | Undetected | 6,902,328 | 4,845,925 | 5,744,321 |
| PCV (%) | 37.3 ± 0.38 | 30 | 31 | 36 | 33 | 36 | 33 | 32 | 29 | 30 | 31 |
| RBC (×10 6 cells/μL) | 3.10 ± 0.03 | 2.81 | 2.93 | 3.37 | 3.08 | 3.33 | 3.02 | 2.88 | 2.73 | 3.29 | 2.95 |
| WBC (cells/μL) | 18825 ± 351 | 16,230 | 17,760 | 20,640 | 22,300 | 15,370 | 15,010 | 14,140 | 10,110 | 14,300 | 8330 |
| Heterophils (cells/μL) | 4247 ± 136 | 3246 | 2309 | 7018 | 10,704 | 4765 | 3753 | 3394 | 5561 | 8065 | 5081 |
| Lymphocytes (cells/μL) | 10,675 ± 358 | 10,063 | 12,077 | 8050 | 9143 | 9222 | 8256 | 7353 | 2325 | 2054 | 1833 |
| Monocytes (cells/μL) | 3459 ± 219 | 2434 | 2842 | 5366 | 2230 | 1383 | 3002 | 2969 | 2224 | 700 | 1333 |
| Eosinophile (cells/μL) | 296 ± 28 | 487 | 532 | 206 | 618 | 0 | 0 | 428 | 143 | 0 | 83 |
| Platelets (×10 3 cells/μL) | 458 ± 8 | 515 | 553 | 802 | 541 | 459 | 580 | 540 | 194 | 98 | 74 |
| Monocyte/Heterophil ratio | 0.87 ± 0.05 | 0.75 | 1.23 | 0.76 | 0.21 | 0.29 | 0.80 | 0.87 | 0.40 | 0.09 | 0.26 |
| Salivary cortisol (ng/mL) | 1.17 ± 0.08 | 1.03 | 0.91 | 1.57 | 0.78 | 1.27 | 0.40 | 0.39 | No sample | No sample | No sample |
| FGM (ng/g) | 36.1 ± 3.19 | 72.30 | 62.59 | 34.37 | 39.26 | 103.11 | 48.73 | 15.56 | No sample | No sample | No sample |
| SIgA (µg/mL) | 3.53 ± 0.31 | 3.70 | 4.98 | 5.50 | 5.04 | 5.49 | 2.78 | 1.70 | No sample | No sample | No sample |
| FIgA (µg/mL) | 1.85 ± 0.10 | 2.42 | 2.57 | 1.41 | 1.55 | 12.22 | 2.57 | 0.94 | No sample | No sample | No sample |