. 2021 Sep 7;22(18):9694. doi: 10.3390/ijms22189694

Table 2.

Laboratory and clinical investigations of the reported cases in the section on vitamin B₁₂ and neurological disorders, with main changes after treatment.

References	Laboratory and Clinical Investigations	Main Changes after Treatment
Ralapanawa et al. [34]	Full blood profile, serum creatinine, plasma glucose, thyroid stimulating hormone levels, vitamin B₁₂ levels, nerve conduction studies	After 3 months, clinical improvement, with repeated B₁₂ levels being elevated up to 308.6 pg/mL. Follow up at 1 and 3 years showed improvement of nerve conduction.
Ekabe et al. [35]	Full blood profile, HIV test, Treponema pallidum hematoglutinin assay (TPHA), erythrocyte sedimentation rate and peripheral blood smear analysis, stool exam and urinalysis	At 1 months follow up good clinical recovery, improvement in neurological symptoms and a follow up MCV of 97 fl, red blood cell count of 4.1 million/µL, and reticulocyte count of 0.95%.
Maamar et al. [36]	Full blood profile, Somatosensorial evoked potential (SEP), MRI, vitamin B₁₂ levels, Folate levels, bone marrow biopsy	Correction of the neurological signs (paresthesis and sphincter disorders).
Senol et al. [37]	Blood glucose, AST, ALT, blood urea nitrogen, creatinine, Hb, MCV, white blood cell count, sedimentation rate, Vitamin B₁₂ levels, HbA1C level, Somatosensorial evoked potential (SEP), Electromyography, Gastric endoscopy and biopsy, Brain MR, Cervical spine MR imaging	At two months follow up complete resolution of symptoms, MR imaging abnormalities significantly improved; impairment of the Somatosensorial evoked potential continued.
Srikanth et al. [38]	Full blood profile, bone marrow biopsy, Visual evoked potential and brain stem evoked potential studies, Gastric endoscopy and biopsy, workups for infections, para infectious myelitis, multiple sclerosis and connective tissue disorders, Folate levels, vitamin B₁₂ levels, cervical MR examination	At 10 months follow-up, MRI revealed total resolution of cord abnormality.
Kumar [39]	Full blood profile, bone marrow biopsy, vitamin B₁₂ levels, Folate levels, Anti-intrinsic factor antibody Gastric endoscopy and biopsy, Brain CT scan, EEG	At 24 months follow-up resolution of seizure and functional independence.
Mavromati & Sentissi [40]	Full blood profile, Electrolytes, vitamin B₁₂ levels, Folate levels, Lyme’s test brain MRI, Neuropsychiatric tests	At 1 week normalization of vitamin B₁₂ level (330 pmol/L); at 2 weeks important diminution of the cognitive deficiency and a partial remission of the depressive symptoms (MADRS score 22, MMSE 28/30 and DRS-R-98 4; the clock test was normalised). Four weeks after the episode total remission of the depressive symptoms (MADRS score: 4) and stable mental status.