Figure 4.

Progression-free survival (PFS) curves in the carriers of TSPO rs6971 polymorphism stratified by genotype, biological sex, and treatment, using the CCF cohort. (A) Overall recurrence probability curves in the entire population (left panel), male subgroup (middle panel), and female subgroup (right panel) comparing the wild-type A/A, heterozygous A/G, and variant G/G genotypes for the TSPO rs6971 polymorphism using patient data from the CCF cohort. (B) Overall recurrence probability curves stratifying by treatment (those who underwent surgical resection followed by standard of care treatment) in the entire population (left panel), the male subgroup (middle panel), and the female subgroup (right panel) comparing the wild-type A/A, heterozygous A/G, and variant G/G genotypes for the TSPO rs6971 polymorphism. Genotype patient numbers and p-values are indicated in each graph, and the median and statistical data are in Table 1.