Table 1.
Patient Characteristics by TSPO rs6971 polymorphism genotype from the CCF dataset.
| Characteristics | Overall N = 441 1 |
G/G Variant N = 232 1 |
A/G Heterozygous N = 175 1 |
A/A Wild Type N = 34 1 |
p-Value 2 |
|---|---|---|---|---|---|
| Age at Diagnosis | 61 (53, 70) | 61 (53, 70) | 61 (54, 70) | 54 (46, 67) | 0.056 |
| Sex | >0.9 | ||||
| Female | 145 (33%) | 76 (33%) | 57 (33%) | 12 (35%) | |
| Male | 296 (67%) | 156 (67%) | 118 (67%) | 22 (65%) | |
| Surgery | 0.9 | ||||
| Gross Total Resection | 152 (49%) | 79 (49%) | 59 (48%) | 14 (48%) | |
| Near Total Resection | 73 (23%) | 37 (23%) | 31 (25%) | 5 (17%) | |
| Subtotal Resection | 88 (28%) | 46 (28%) | 32 (26%) | 10 (34%) | |
| Unknown | 128 | 70 | 53 | 5 | |
| Standard of Care | 03 | ||||
| No | 66 (15%) | 36 (16%) | 28 (16%) | 2 (5.9%) | |
| Yes | 375 (85%) | 196 (84%) | 147 (84%) | 32 (94%) | |
| KPS | >0.9 | ||||
| <=70 | 62 (14%) | 32 (14%) | 25 (15%) | 5 (15%) | |
| 70+ | 370 (86%) | 195 (86%) | 147 (85%) | 28 (85%) | |
| Unknown | 9 | 5 | 3 | 1 | |
| Overall Survival (Months) | 14 (7, 26) | 13 (7, 27) | 12 (6, 20) | 25 (16, 52) | <0.001 |
| Vital Status | 0.009 | ||||
| Alive | 42 (9.6%) | 31 (13%) | 8 (4.6%) | 3 (8.8%) | |
| Deceased | 397 (90%) | 200 (87%) | 166 (95%) | 31 (91%) | |
| Unknown | 2 | 1 | 1 | 0 | |
| Progression Free Survival | 6 (3, 12) | 7 (3, 13) | 5 (3, 10) | 9 (4, 27) | 0.003 |
| Recurrence | 0.5 | ||||
| No | 114 (26%) | 60 (26%) | 48 (28%) | 6 (18%) | |
| Yes | 323 (74%) | 169 (74%) | 126 (72%) | 28 (82%) | |
| Unknown | 4 | 3 | 1 | 0 |
1 Median (IQR); n (%) 2 Kruskal–Wallis rank-sum test; Pearson’s chi-square test; Fisher’s exact test. Note: Unknown demographic and clinical characteristics are included in the table but are not assessed in statistical tests.