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. 2021 Sep 8;13(18):4525. doi: 10.3390/cancers13184525

Table 1.

Patient Characteristics by TSPO rs6971 polymorphism genotype from the CCF dataset.

Characteristics Overall
N = 441 1
G/G
Variant
N = 232 1
A/G
Heterozygous
N = 175 1
A/A
Wild Type
N = 34 1
p-Value 2
Age at Diagnosis 61 (53, 70) 61 (53, 70) 61 (54, 70) 54 (46, 67) 0.056
Sex >0.9
Female 145 (33%) 76 (33%) 57 (33%) 12 (35%)
Male 296 (67%) 156 (67%) 118 (67%) 22 (65%)
Surgery 0.9
Gross Total Resection 152 (49%) 79 (49%) 59 (48%) 14 (48%)
Near Total Resection 73 (23%) 37 (23%) 31 (25%) 5 (17%)
Subtotal Resection 88 (28%) 46 (28%) 32 (26%) 10 (34%)
Unknown 128 70 53 5
Standard of Care 03
No 66 (15%) 36 (16%) 28 (16%) 2 (5.9%)
Yes 375 (85%) 196 (84%) 147 (84%) 32 (94%)
KPS >0.9
<=70 62 (14%) 32 (14%) 25 (15%) 5 (15%)
70+ 370 (86%) 195 (86%) 147 (85%) 28 (85%)
Unknown 9 5 3 1
Overall Survival (Months) 14 (7, 26) 13 (7, 27) 12 (6, 20) 25 (16, 52) <0.001
Vital Status 0.009
Alive 42 (9.6%) 31 (13%) 8 (4.6%) 3 (8.8%)
Deceased 397 (90%) 200 (87%) 166 (95%) 31 (91%)
Unknown 2 1 1 0
Progression Free Survival 6 (3, 12) 7 (3, 13) 5 (3, 10) 9 (4, 27) 0.003
Recurrence 0.5
No 114 (26%) 60 (26%) 48 (28%) 6 (18%)
Yes 323 (74%) 169 (74%) 126 (72%) 28 (82%)
Unknown 4 3 1 0

1 Median (IQR); n (%) 2 Kruskal–Wallis rank-sum test; Pearson’s chi-square test; Fisher’s exact test. Note: Unknown demographic and clinical characteristics are included in the table but are not assessed in statistical tests.