Table 2.
Patient Characteristics by TSPO rs6971 polymorphism genotype from the CWRU dataset.
| Characteristic | Overall N = 131 1 |
G/G Variant N = 54 1 |
A/G Heterozygous N = 67 1 |
A/A Wild Type N = 10 1 |
p-Value 2 |
|---|---|---|---|---|---|
| Age at Diagnosis | 64 (55, 69) | 64 (55, 70) | 62 (56, 68) | 62 (50, 71) | 0.5 |
| Sex | 0.014 | ||||
| Female | 47 (36%) | 12 (22%) | 29 (43%) | 6 (60%) | |
| Male | 84 (64%) | 42 (78%) | 38 (57%) | 4 (40%) | |
| Surgery | 0.7 | ||||
| Gross Total Resection | 75 (59%) | 33 (62%) | 37 (57%) | 5 (50%) | |
| Subtotal Resection | 53 (41%) | 20 (38%) | 28 (43%) | 5 (50%) | |
| Unknown | 3 | 1 | 2 | 0 | |
| Standard of Care | 0.7 | ||||
| No | 45 (37%) | 20 (39%) | 21 (33%) | 4 (44%) | |
| Yes | 78 (63%) | 31 (61%) | 42 (67%) | 5 (56%) | |
| Unknown | 8 | 3 | 4 | 1 | |
| KPS | 0.7 | ||||
| ≤70 | 56 (60%) | 23 (61%) | 29 (62%) | 4 (44%) | |
| 70+ | 38 (40%) | 15 (39%) | 18 (38%) | 5 (56%) | |
| Unknown | 37 | 16 | 20 | 1 | |
| Overall Survival (Months) | 12 (5, 21) | 10 (5, 16) | 13 (6, 22) | 18 (9, 24) | 0.4 |
| Vital Status | 0.7 | ||||
| Alive | 3 (2.3%) | 2 (3.7%) | 1 (1.5%) | 0 (0%) | |
| Deceased | 128 (98%) | 52 (96%) | 66 (99%) | 10 (100%) | |
| Progression Free Survival | 8 (4, 12) | 6 (4, 10) | 10 (5, 13) | 9 (5, 17) | 0.11 |
| Unknown | 57 | 22 | 32 | 3 | |
| Recurrence | 0.6 | ||||
| No | 56 (43%) | 22 (41%) | 31 (47%) | 3 (30%) | |
| Yes | 74 (57%) | 32 (59%) | 35 (53%) | 7 (70%) | |
| Unknown | 1 | 0 | 1 | 0 |
1 Median (IQR); n (%) 2 Kruskal–Wallis rank-sum test; Fisher’s exact test Note: Unknown demographic and clinical characteristics are included in the table but are not assessed in statistical tests.