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. 2021 Sep 7;13(9):1415. doi: 10.3390/pharmaceutics13091415

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Physicochemical properties of the prepared PLGA NPs formulations. (A,B) TEM images of CBD-loaded PLGA NPs and CS-coated CBD-loaded PLGA NPs, respectively. (C) Encapsulation efficiency of CBD/PLGA NPs and CS-CBD/PLGA NPs were measured by HPLC. (D) FTIR spectra of (a) PLGA NPs, (b) CS and (c) CS-coated PLGA NPs. (E) Changes in particle size and EE of CS-coated CBD-loaded PLGA NPs at 4 and 25 °C for 2 and 5 weeks, respectively. In vitro cumulative release of the CBD from bare (F) and CS-coated (G) PLGA NPs in PBS for 110 h at pH 5.0 and 6.5, respectively. Data are expressed as mean ± SD (n = 3). * p < 0.05 compared to the control.