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. 2021 Sep 10;9(9):1198. doi: 10.3390/biomedicines9091198

Figure 1.

Figure 1

Representative pictures of the distribution of hepatic fibrotic tissue in control and NASH (stage F3) guinea pigs in Picro Sirius red stained sections. (A) In control animals, fibrous tissue (red) surrounds the central veins and portal areas, but does not expand into the hepatic parenchyma. An isolated small area of fibroplasia (arrowhead) can be seen as a normal occasional finding. (B) Bridging fibrosis (arrows) (F3 grade) is clearly evident in animals with NASH after 25 weeks on a high-fat diet.