Table 3.
Top 20 differentially expressed genes in guinea pigs.
| Gene Name (Full Name) | Log2 Fold Change | Adjusted p-Value | Function |
|---|---|---|---|
| ADAMDEC1 (ADAM like decysin 1) | 8.01 | 4.94 ×10−60 | Secreted protein invovled in dendritic cell maturation. |
| ADGRG3 (adhesion G protein-coupled receptor 3) | 7.66 | 3.79 × 10−40 | GPCR possibly invovled tumor angiogenesis. |
| KRT23 (keratin 23) | 10.97 | 1.53 × 10−35 | Member of keratin family of intermediate filaments responsible for structural integrity of epithelial cells. |
| ATP6V0A4 (ATPase H + transporting V0 subunit a4) | 9.02 | 3.01 × 10−32 | Vacuolar ATPase mediating acidification of intracellular compartments necessary for protein sorting, zymogen activation, receptor-mediated endocytosis and synaptic vesicle protein gradient generation. |
| TMEM213 (transmembrane protein 213) | 10.12 | 1.28 × 10−29 | No listed function. |
| CIB4 (calcium and integrin binding family member 4) | −9.70 | 1.82 × 10−26 | No listed function. |
| PAK6 (p21 (RAC1) activated kinase 6) | 9.38 | 5.69 × 10−26 | p21 stimulated serine/threonine kinase involved in cytoskeleton rearrangement, apoptosis and MAP kinase signalling pathway. |
| TMC1 (transmembrane channel like 1) | 9.27 | 1.82 × 10−25 | No listed function. |
| CCL7 (C–C motif chemokine ligand 7) | 9.09 | 2.30 × 10−25 | Encodes MCP3-a secreted chemokine recruiting macrophages during inflammation, and also a substrate of MMP2. |
| PTPRN (protein tyrosine phosphatase receptor type N) | 9.23 | 2.58 × 10−24 | Signalling molecule regulating processes such as cell growth, differentiation, mitotic cycle, and oncogenic transformation. |
| VSIG1 (V-set and immunoglobulin domain containing 1) | 8.26 | 1.06 × 10−22 | Encodes a member of the junctional adhesion molecule (JAM) family. |
| SLC34A2 (solute carrier family 34 member 2) | 8.49 | 1.13 × 10−20 | pH-sensitive sodium-dependent phosphate transporter |
| DSG4 (desmoglein 4) | 8.15 | 2.78 × 10−19 | Desmosomal cadherin possibly playing a role in cell–cell adhesion in epithelial cells. |
| TNFSF18 (TNF super family member 18) | 7.74 | 1.92 × 10−17 | Cytokine belonging to the TNF ligand family that plays a role in T-lymphocyte survival and the interaction between endothelial cells and T lymphocytes. |
| MTHFD2 (methylenetetrahydrofolate dehydrogenase (NADP + dependent) 2, methenyltetrahydrofolate cyclohydrolase) | 7.63 | 6.53 × 10−17 | Nuclear encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. |
| SPOCK1 (SPARC (osteonectin), cwcv and kazal-like domains proteoglycan 1) | 7.72 | 8.38 × 10−17 | Seminal plasma proteoglycan containing chondroitin and heperan sulfate chains. |
| ECT2 (epithelial cell transforming 2) | 8.43 | 5.94 × 10−16 | Guanine nucleotide exchange factor, expressed at high levels in mitotic cells in the regenerating liver. |
| SPTA1 (spectrin alpha, erythrocytic 1) | 7.99 | 7.35 × 10−15 | Molecular scaffold protein that links the plasma membrane to the actin cytoskeleton and determines the cell shape. |
| STAR (steroidogenic acute regulatory protein) | 8.36 | 2.48 × 10−14 | Involved in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnolone. |
| KEL (Kell metalloendopeptidase (Kell blood group)) | 7.66 | 1.34 × 10−12 | Encodes a type II transmembrane glycoprotein of the Kell blood group antigen. |
List of top 20 differentially expressed genes in the guinea pig dataset based on log2 fold change and Benjamini–Hochberg adjusted p-value. GPCR: G protein-coupled receptor, MAP: mitogen-activated protein, MCP: monocyte chemotactic protein, MMP: matrix metalloproteinase, TNF: tumour necrosis factor.