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. 2021 Sep 6;11(9):1315. doi: 10.3390/biom11091315

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Expression of Cu regulatory mRNAs following CuD or CuO treatment. Expressions of mRNAs encoding Cu regulatory proteins were quantified by qPCR. (A). Ctr1 mRNA expressions in the choroid plexus (CP) and OB. (B). Dmt1 mRNA expressions in the CP and OB. (C). Mt1a mRNA expressions in the SVZ and OB. (D) Mt2a mRNA expressions in the SVZ and OB. (E) Mt3 mRNA expressions in the SVZ and OB. Data represents mean ± SEM, n = 6–7/group. *: p < 0.05, **: p < 0.01, ***: p < 0.001, as compared to the correspondent Ct group; ∆: p < 0.05, ∆∆∆: p < 0.001, as compared with the correspondent CuD group; using one-way ANOVA analysis. Ct: control; CuD: Cu deficiency; CuO: Cu overload; SVZ: subventricular zone; OB: olfactory bulb.