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. 2021 Sep 16;22(18):10021. doi: 10.3390/ijms221810021

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Schematic representation of NCAM2 functions and interactions during brain development. (a) NCAM2 is involved in neuronal migration, NCAM2 protein levels have been associated with an aberrant neuronal migration and layering positioning in the cortex. NCAM2 interacts with different cytoskeletal associated proteins which control cytoskeleton dynamics during neuronal migration. (b,c) NCAM2 has a crucial role during neuronal differentiation interacting with different proteins that are necessary for dendritic tree development and axon elongation. NCAM2 depletion alters the growth cone mobility and microtubules stability. Microtubule associated protein 1B, MAP1B; Microtubule associated protein 2, MAP2; and Calcium/calmodulin-dependent protein kinase type II, CaMKII. Lissencephaly-1/Nuclear distribution protein nudE-like1, LIS/NDEL; radial glia progenitors, RGP; marginal zone, MZ; and ventricular zone, VZ.