Table 3.

NCAM2 implications in neurodevelopmental disorders and neurodegenerative diseases.

Neurodevelopmental Disorder
Disorder	Type of Study	Implications	References
Autism Spectrum Disorders	Genetic in humans	Genetic studies associate alterations and deletions in Ncam2 with ASD.	[23,164,165]
Down Syndrome	Genetic in humans	Increased expression in DS patients due to the location of Ncam2 in the 21 chromosome.	[67,166]
Other neurodevelopmental disorders	Genetic in humans	Deletions Ncam2 are found in patients with neurodevelpmental disorders.	[167]
Neurodegenerative diseases
Disorder		Implications	References
Alzheimer’s Disease	Genetic in humans	Alterations in Ncam2 found in AD patients.	[168,169]
	Experimental with human and mouse samples.	β-amyloid induces proteolysis of synaptic NCAM2.	[76]
Frontotemporal dementia	Experimental with mouse tissue samples	NCAM2 proposed as a candidate receptor for GRN	[70]