Figure 1.

Idebenone significantly decreases Aβ pathology in a mouse model of AD. (a) Representative images of cortical and hippocampal 6E10 immunofluorescent staining. Idebenone or vehicle was administered daily to 3-month-old mice for 14 consecutive days, as shown at the top of the figure. Immunostaining of brain sections with anti-6E10 was subsequently performed. (b) Quantification of the results (n = 16 brain slices from four mice/group). *** p < 0.001 vs. vehicle-treated control. Scale bar = 200 μm.