Figure 3.

Idebenone significantly suppresses cleaved caspase-3 levels in a mouse model of AD. (a) Representative images of cleaved caspase-3 immunofluorescent staining in the cortex and hippocampus. Idebenone or vehicle was administered daily to 3-month-old mice for 14 consecutive days as shown at the top of the figure. Immunostaining of brain sections with anti-caspase-3 was then performed. (b) Quantification of the results (n = 14–17 brain slices from 4 mice/group). *** p < 0.001 vs. vehicle-treated control. Scale bar = 100 μm for cortex and 200 μm for hippocampus.