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. 2021 Sep 19;10(9):938. doi: 10.3390/biology10090938

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Idebenone significantly upregulates NEP levels in a mouse model of AD. (a,b) Representative images of cortical and hippocampal NEP and IDE immunofluorescent staining. Idebenone or vehicle was administered daily to 3-month-old mice for 14 consecutive days, as shown at the top of the figure. Immunostaining of brain sections was then performed with anti-NEP and anti-IDE. (c) Quantification of the results (n = 16 brain slices from four mice/group). ** p < 0.01 and *** p < 0.001 vs. vehicle-treated control. Scale bar = 100 μm for cortex and 200 μm for hippocampus.