Boxplots for absolute (Vmax) and substrate turnover of peptides used and inhibitors (Vmax), relative (% TOTAL-ACT) substrate utilization across peptides (Peptides A–E), and contribution of inhibitor-doped samples (% Inhibition). Sample types were WMS, based on caries status (CAR/NO-CAR), and caries biopsy (BIOP) samples for the five peptides studied. Inhibitor data is expressed as Vmax contribution to signal and % inhibition by either Metalloproteases (MMPi), CSC proteases (COMi) or combined MMPi and COMi (BOTHi). relative (%CONT; percentage contribution to turnover; %Inhibition: Percentage inhibition of overall activity).