Table 4.
Effects of adolescent cannabinoid exposure on subsequent drug use.
| Cannabinoid | Dose | Strains | Gender | Effect | Drug of Abuse | Reference |
|---|---|---|---|---|---|---|
| WIN55,212-2 | 2, 4, 8 mg/kg | Sprague Dawley rats | M and F | M✓ F✓ | Morphine/Amphetamine | [123] |
| Δ9-THC | 1.5 mg/kg | Long–Evans rats | M | ✓ | Heroin | [40] |
| CP-55,940 | 0.2, 0.4 mg/kg | Wistars rats | M and F | M✓ F✗ | Morphine | [125] |
| WIN55,212-2 | 1, 2, 4 mg/kg | Sprague Dawley rats | M | ✓ | Morphine | [126] |
| WIN55,212-2 | 1, 2, 4 mg/kg | Sprague Dawley rats | F | ✓ | Morphine | [127] |
| Δ9-THC | 2.5, 5.0, 10 mg/kg | Wistar rats | M | ✗ | Heroin | [41] |
| Δ9-THC | 2.0, 4.0, 8.0 mg/kg | Fischer 344 and Lewis rats | M | Fischer 344✓ Lewis rats✗ | Heroin | [124] |
| WIN55,212-2 | 1.25 mg/kg | Sprague Dawley | M | ✗ | Amphetamine | [128] |
| WIN55,212-2 | 0.0625, 1.25, 2.5 mg/kg | Sprague Dawley | M | ✗ | Amphetamine | [128] |
| WIN55,212-2 | 2, 4, 8 mg/kg | Sprague Dawley | M | ✗ | Cocaine | [129] |
| Δ9-THC | 0.075, 1.5, 3.0 mg/kg | Sprague Dawley | M | ✗ | Amphetamine | [128] |
| Δ9-THC | 1.5 mg/kg | Sprague Dawley | M | ✗ | Amphetamine | [128] |
| Δ9-THC | 0.1 and 1.0 mg/kg | Sprague Dawley | M | ✓ | Amphetamine | [130] |
| Δ9-THC | 0.1 and 1.0 mg/kg | Sprague Dawley | M | ✓ | Δ9-THC | [130] |
| CP-55,940 | 0.4 mg/kg | Wistar rats | M and F | M✗ F✓ | Cocaine | [131] |
| CP-55,940 | 0.4 mg/kg | Wistar rats | M and F | M✗ F✓ | Cocaine | [131] |
| CP-55,940 | 0.4 mg/kg | Wistar rats | M and F | M✗ F✓ | Cocaine | [132] |
| HU-210 | 25, 50, 100 µg/kg | Sprague Dawley rats (Exp 1) | M and F | M✓ F✗ | Amphetamine | [46] |
| HU-210 | 25, 50, 100 µg/kg | Sprague Dawley rats (Exp 2) | M and F | M✗ F✓ | Amphetamine | [46] |
(✗): no significant effect of cannabinoid on activity of another drug. (✓): significant effect of cannabinoid on activity of another drug. (M): male. (F): female.