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. 2021 Sep 11;13(18):4560. doi: 10.3390/cancers13184560

Figure 2.

Figure 2

Evolution over time of (a) tumor volume, (b) Time To Peak (TTP), (c) colocalization of apoptosis and vascular endothelium (VE ∩ AP), (d) Wash-Out Rate (WOR), and (e) Wash-In Rate (WIR). For tumor volume (a) and the contrast parameters TTP (b), the values at D10 are significantly different to the values at D14, D16, and D17. The immunohistological parameter VE ∩ AP (b) shows significant difference between D10 and D14. The contrast parameters WOR (d) and WIR (e) show significant differences between D10 and D17. Initial measurements at D7 are shaded in grey because previous studies in this model suggest that the tumor fragment is not yet biologically integrated into the host prior to D9. The raw data and associated boxplot are overlaid; * = p < 0.05, + = outliers.