Table 1.
Evolution of the median (interquartile range) of the following parameters over time: tumor volume (mm3), histological parameters (percent area occupied by nuclei (NU), the number of T Lymphocytes per mm² (NTL), the percent area of apoptosis (AP), and percent area of vascular endothelium (VE), and their spatial standard deviation σ, and the co-localization of a high VE and AP (VE ∩ AP)), the SWE parameters (mean and standard deviation σ in kPa), and CEUS parameters (Area Under the Curve (AUC), Peak Enhancement (PE), Time to Peak (TTP), Mean Transit Time (MTT), Wash-In Rate (WIR), and Wash-Out Rate (WOR)).
| Parameters | D7 | D10 | D14 | D16 | D17 |
|---|---|---|---|---|---|
| Volume | 28.3 (9.7) | 64.4 (22.7) | 554.4 (263.4) | 862.6 (369.3) | 978.1 (510.3) |
| NU | 29.98 (−) | 55.42 (7.77) | 58.15 (13.36) | 46.17 (0.99) | 48.04 (3.83) |
| σ NU | 19.71 (−) | 18.57 (1.19) | 17.55 (3.64) | 20.15 (3.94) | 17.79 (1.47) |
| NTL | 861.18 (−) | 597.38 (143.19) | 636.09 (233.60) | 282.78 (61.15) | 321.02 (76.50) |
| σ NTL | 2.88 × 103 (−) | 760.49 (148.61) | 637.93 (289.35) | 527.22 (129.09) | 361.31 (105.64) |
| AP | 2.29 (−) | 2.36 (0.74) | 1.00 (0.56) | 0.80 (0.92) | 1.63 (0.84) |
| σ AP | 3.63 (−) | 5.28 (2.26) | 2.70 (0.56) | 2.92 (1.95) | 4.78 (2.06) |
| VE | 27.32 (−) | 38.49 (21.98) | 37.48 (5.02) | 20.18 (15.26) | 32.93 (7.02) |
| σ VE | 19.50 (−) | 18.21 (0.91) | 16.58 (2.72) | 13.14 (4.57) | 15.39 (2.50) |
| VE ∩ AP | 11.24 (−) | 12.97 (4.65) | 4.36 (3.13) | 4.05 (2.49) | 8.25 (3.11) |
| SWE | 10.8 (3.3) | 12.9 (4.5) | 16.2 (3.9) | 17.4 (2.9) | 16.6 (2.2) |
| σ SWE | 3.0 (1.1) | 3.6 (0.4) | 5.4 (1.3) | 6.5 (1.7) | 5.8 (0.6) |
| AUC | 3.21 (0.84) | 5.56 (2.32) | 6.48 (3.35) | 6.33 (1.29) | 4.66 (2.52) |
| PE | 7.3 × 10−2 (2.7 × 10−2) | 0.12 (4.1 × 10−2) | 9.2 × 10−2 (2.0 × 10−2) | 9.6 × 10−2 (2.3 × 10−2) | 6.0 × 10−2 (2.4 × 10−2) |
| TTP | 6.23 (1.59) | 7.63 (1.33) | 14.77 (6.34) | 15.37 (5.78) | 17.19 (2.67) |
| MTT | 68.53 (22.75) | 64.58 (6.65) | 68.90 (16.70) | 76.22 (15.99) | 67.10 (14.45) |
| WIR | 2.8 × 10−2 (1.2 × 10−2) | 4.0 × 10−2 (1.7 × 10−2) | 1.6 × 10−2 (6 × 10−3) | 1.5 × 10−2 (5 × 10−3) | 7 × 10−3 (1 × 10−3) |
| WOR | −2 × 10−3 (2 × 10−3) | −3 × 10−3 (6 × 10−4) | −2 × 10−3 (1 × 10−4) | −2 × 10−3 (3 × 10−4) | −9 × 10−4 (2 × 10−4) |