Table 1.
Baseline characteristics.
| All Patients (n = 3821) | |||
|---|---|---|---|
| Female (n = 2149) | Male (n = 1672) | p Value | |
| Clinical Characteristics | |||
| Age | 83 ± 6 | 81 ± 6 | <0.001 |
| Weight | 65 ± 14 | 75 ± 12 | <0.001 |
| BMI | 26 ± 5 | 26 ± 4 | <0.001 |
| Hypertension | 84.5% (1807/2138) | 81.3% (1351/1662) | 0.008 |
| Diabetes | 27.7% (588/2123) | 33.0% (546/1656) | <0.001 |
| CAD | 31.7% (651/2056) | 49.8% (799/1604) | <0.001 |
| Previous MI | 10.8% (222/2058) | 22.9% (370/1615) | <0.001 |
| Previous PCI | 21.2% (444/2094) | 33.2% (543/1634) | <0.001 |
| Previous CABG | 5.9% (126/2149) | 21.2% (355/1672) | <0.001 |
| Previous Stroke | 5.0% (76/1513) | 7.7% (95/1227) | 0.003 |
| Previous PM | 10.5% (215/2043) | 16.2% (259/1594) | <0.001 |
| PAD | 16.2% (348/2149) | 25.7% (430/1672) | <0.001 |
| Severe COPD | 14.0% (301/2149) | 23.6% (395/1672) | <0.001 |
| NYHA III/IV | 77.4% (1544/1995) | 76.8% (1201/1564) | n.s |
| Hemoglobin | 11.6 ± 1.5 | 12.2 ± 1.8 | <0.001 |
| eGFR < 30 mL/min | 26.3 | 16.3 | <0.001 |
| LogEuroscore | 19.2 ± 13.3 | 19.8 ± 15.5 | n.s |
| STS | 7.8 ± 7.1 | 7.2 ± 7.5 | <0.001 |
| ECG Features | |||
| LBBB | 8.7% (186/2149) | 8.5% (142/1672) | n.s |
| RBBB | 5.1% (109/2149) | 8.4% (140/1672) | <0.001 |
| LAHB | 7.7% (165/2149) | 9.3% (156/1672) | n.s. |
| Any of above | 19.4% (416/2149) | 22.7% (379/1672) | 0.012 |
| Echocardiographic Parameters | |||
| LVEF | 54.3 ± 11.2 | 49.7 ± 12.7 | <0.001 |
| Mean aortic gradient | 52.4 ± 15.3 | 47.3 ± 12.8 | <0.001 |
| Aortic regurgitation 2+ | 28.8% (534/1853) | 29.1% (425/1459) | n.s. |
| Mitral regurgitation 2+ | 43.4% (855/1969) | 37.4% (565/1510) | <0.001 |
| sPAP < 60 mmHg | 9.4% (163/1738) | 8.2% (106/1293) | n.s. |
| Procedural Characteristics | |||
| General anesthesia | 24.5% (509/2076) | 24.9% (402/1613) | n.s. |
| Access | |||
| Femoral Subclavian Aortic Other |
87.2% (1856/2129) 9.1% (194/2129) 3.6% (76/2129) 0.1% (3/2129) |
82.1% (1363/1661) 14.1% (234/1661) 3.5% (58/1661) 0.4% (6/1661) |
<0.001 |
| Prothesis Type | |||
| Corevalve Evolut Pro Evolut R |
55.2% (1180/2137) 9.6% (206/2137) 35.1% (751/2137) |
59.1% (983/1664) 6.1% (102/1664) 34.8% (579/1664) |
< 0.001 |
| Pre-dilation | 69.1% (1216/1761) | 70.1% (955/1363) | n.s. |
| Prothesis Size | |||
| 23 mm 26 mm 29 mm 31 mm 34 mm |
6.5% (136/2096) 63.6% (1334/2096) 28.1% (589/2096) 0.8% (16/2096) 1.0% (21/2096) |
0.9% (14/1631) 13.2% (215/1631) 62.9% (1026/1631) 11.0% (179/1631) 12.1% (197/1631) |
<0.001 |
| Post-dilation | 25.6% (501/1954) | 31.7% (485/1530) | <0.001 |
| Procedural time | 110.8 ± 51.9 | 113.8 ± 50.0 | 0.040 |
| Fluoroscopy time | 24.0 ± 15.9 | 26.2 ± 49.5 | 0.042 |
| Contrast amount | 165.0 ± 101.0 | 174.0 ± 87.2 | <0.001 |
| Procedural success | 97.5% (2091/2145) | 95.8% (1599/1669) | 0.004 |
BMI = body mass index; CAD = coronary artery disease; MI = myocardial infarction; PCI = percutaneous coronary intervention; CABG = coronary artery by-pass graft; PM = pace maker; PAD = peripheral artery disease; COPD = chronic obstructive pulmonary disease; NYHA = New York heart association; GFR = glomerular filtration rate; STS = society of thoracic surgeons; LBBB = left bundle branch block; RBBB = right bundle branch block; LAHB = left anterior hemi-block; AF = atrial fibrillation; LVEF = left ventricular ejection fraction; PAPs = pulmonary artery pressures.