Figure 5.

Effect of tropoelastin-based conditioned media from MSC cultures on endothelial network branching and mesh formation. Networks forming at 5 h in the presence of conditioned media from MSCs cultured with (A) or without (B) tropoelastin. Panels (C,D) are magnified sections from (A,B). Panels (E,F) represent these networks at 7 h. White arrows point to spaces formed by branches that had not anastomosed to form continuous segments. Black arrows point to an example of open areas that were enclosed by 7 h. Gray-shaded areas highlight differences in mesh characteristics.