Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Sep 14;22(18):9939. doi: 10.3390/ijms22189939

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Kinome profiling and in silico workflow for the identification of MC-LR-induced kinase activity and potential inhibitory compounds. (A) Schematic summarizing the overall workflow. Gene expression profiles derived from kinome profiles and published MC-LR exposure gene expression profiles were compared against perturbagen signatures in iLINCS to generate a list of hypothetical inhibitory compounds for the MC-LR-induced kinase activity. (B) Kinase activity from the serine/threonine kinase (STK) (C) and tyrosine kinase (PTK) arrays. (D) Identified hypothetical inhibitory compounds ranked by their inverse concordance with the MC-LR-induced signatures.