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Synthesis of “piperazinyl” derivatives. Reagents and conditions: (a) Ac2O, pyridine, 12 h, RT; (b) i. (COCl)2, DCM, DMF, 2 h, RT, ii. 1-(2-N-boc-aminoethyl)piperazine, Et3N, DCM, 12 h, RT; (c) 4M NaOH, THF-MeOH, 3 h, RT; (d) 2M HCl/Et2O, 12 h, RT (under argon); (e) BODIPY-SMe, CHCl3-THF, Et3N, 30 min, RT; (f) 2,2-dimethyl succinic anhydride, 4-DMAP, p-TsOH, THF, 2 h, MW-130 °C.
