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Caveolae mediate SR-BI-dependent uptake of cholesterol esters from HDL. HDL cholesterol esters are initially associated with plasma membrane caveolae. While in caveolae, cholesterol esters may either efflux back to HDL or translocate to nonreversible pools within the plasma membrane or an intracellular membrane compartment. The mechanism for internalization of caveolar cholesterol esters remains unknown.
