Figure 1.

Depiction of the structure, the main regulatory phosphosites (using the amino acid sequence corresponding to mouse Vav1), the intramolecular autoinhibitory interactions that take place in the nonphosphorylated state of Vav proteins (top), and some of the main downstream pathways described for specific mammalian Vav family members (bottom). NFAT, nuclear factor of activated T cells (a transcriptional factor involved in the proliferation and cytokine production of T lymphocytes); ICN1, intracellular domain of Notch1. The rest of abbreviations are described in the main text.