Table 3.
Univariate and multivariate associations of clinicopathologic variables, treatment-related factors, nutritional and inflammatory markers with changes of body composition parameters over the CCRT course in 69 patients with oral cavity cancer undergoing adjuvant CCRT.
| Variables | ΔLBM | ΔΤFM | ΔBMC | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | Univariate | Multivariate | ||||
| p-Value * | Coefficient (95% CI) | p-Value * | p-Value * | Coefficient (95% CI) | p-Value * | p-Value * | Coefficient (95% CI) | p-Value * | |
| Clinicopathologic factor | |||||||||
| Age | 0.001 * | 0.090 (0.028~0.152) | 0.005 * | 0.237 | 0.596 | ||||
| Sex | 0.411 | 0.594 | 0.382 | ||||||
| TNM stage (III vs. IVA vs. IVB) | 0.594 | 0.804 | 0.436 | ||||||
| T status (T1-2 vs. T3-4) | 0.630 | 0.647 | 0.968 | ||||||
| N status (N0-1 vs. N2-3) | 0.486 | 0.899 | 0.492 | ||||||
| Histologic grade (1 vs. 2 vs. 3) | 0.906 | 0.850 | 0.552 | ||||||
| Smoking (no vs. yes) | 0.703 | 0.666 | 0.455 | ||||||
| Alcohol (no vs. yes) | 0.419 | 0.516 | 0.062 | ||||||
| Betel nut (no vs. yes) | 0.803 | 0.374 | 0.483 | ||||||
| ECOG performance status (0:1:2) |
0.480 | 0.433 | 0.310 | ||||||
| HN-CCI (0 vs. 1 vs. 2 vs. ≥3) | 0.556 | 0.707 | 0.552 | ||||||
| Tracheostomy (no vs. yes) | 0.395 | 0.509 | 0.609 | ||||||
| Mean daily calorie intake during CCRT |
0.001 * | 0.102 (0.043~0.162) | 0.001 * | <0.001 * | 0.133 (0.073~0.193) | <0.001 * | 0.141 | ||
| Treatment-associated factors | |||||||||
| CCRT Regimen | |||||||||
| RT dose | 0.958 | 0.658 | 0.192 | ||||||
| RT fractions | 0.587 | 0.368 | 0.237 | ||||||
| RT duration (days) | 0.474 | 0.670 | 0.855 | ||||||
| Cisplatin dose | 0.717 | 0.731 | 0.815 | ||||||
| Grade ¾ toxicity | |||||||||
| Dermatitis (ref: yes) | 0.255 | 0.889 | 0.097 | ||||||
| Pharyngitis (ref: yes) | 0.713 | 0.786 | 0.055 | ||||||
| Infection (ref: yes) | 0.283 | 0.958 | 0.313 | ||||||
| Mucositis (ref: yes) | 0.611 | 0.378 | 0.601 | ||||||
| Emesis (ref: yes) | 0.351 | 0.160 | 0.569 | ||||||
| Anemia (ref: yes) | 0.988 | 0.037 * | 2.550 (0.553~0.538) |
0.014 * | 0.456 | ||||
| Neutropenia (ref: yes) | 0.535 | 0.004 * | 1.675 (0.450~2.899) |
0.009 * | 0.931 | ||||
| Thrombocytopenia (ref: yes) | 0.271 | 0.048 * | 0.944 | ||||||
| NIMs before CCRT | |||||||||
| PG-SGA (well: moderate: severe) | 0.728 | 0.473 | 0.706 | ||||||
| BMI | 0.038 * | <0.001 * | 0.061 | ||||||
| BW | 0.023 * | <0.001 * | 0.030 * | ||||||
| Hb | 0.027 * | 0.469 | 0.848 | ||||||
| WBC | 0.990 | 0.252 | 0.145 | ||||||
| Platelet | 0.071 | 0.353 | 0.199 | ||||||
| TLC | 0.188 | 0.701 | 0.005 * | −0.021 (−0.080~−0.01) |
0.031 * | ||||
| Albumin | 0.350 | 0.330 | 0.983 | ||||||
| CRP | 0.195 | 0.870 | 0.254 | ||||||
* represents a significant p-value. Abbreviations: CCRT, concurrent chemoradiotherapy; HN-CCI, Charlson Comorbidity Index; ECOG, Eastern Cooperative Oncology Group; PG-SGA, patient generated subjective global assessment; RT, radiotherapy; NIMs, nutritional/inflammatory markers; BW, body weight; BMI, body mass index; Hb, hemoglobin; WBC, white blood cell; TLC, total lymphocyte count; CRP, C-reactive protein; LBM, lean body mass; TFM, total fat mass; BMC, bone mineral content. Δ indicates a value obtained by subtracting the pre-CCRT value from the post-CCRT value; CI, confidence interval.