Table 4.
Univariate and multivariate associations of clinicopathologic variables, treatment-related factors, nutritional and inflammatory markers with changes of body composition parameters over the CCRT course in 58 patients with non-oral cavity cancer undergoing primary CCRT.
| Variables | ΔLBM | ΔΤFM | ΔBMC | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | Univariate | Multivariate | ||||
| p-Value * | Coefficient (95% CI) | p-Value * | p-Value * | Coefficient (95% CI) | p-Value * | p-Value * | Coefficient (95% CI) | p-Value * | |
| Clinicopathologic factors | |||||||||
| Age | 0.489 | 0.195 | 0.168 | ||||||
| Sex | 0.154 | 0.772 | 0.627 | ||||||
| TNM stage (III vs. IVA vs. IVB) | 0.565 | 0.443 | 0.538 | ||||||
| T status (T1-2 vs. T3-4) | 0.389 | 0.017 * | 0.563 | ||||||
| N status (N0-1 vs. N2-3) | 0.523 | 0.836 | 0.693 | ||||||
| Histologic grade (1 vs. 2 vs. 3) | 0.658 | 0.265 | 0.590 | ||||||
| Smoking (no vs. yes) | 0.626 | 0.203 | 0.758 | ||||||
| Alcohol (no vs. yes) | 0.234 | 0.071 | 0.919 | ||||||
| Betel nut (no vs. yes) | 0.661 | 0.249 | 0.435 | ||||||
| ECOG performance status (0:1:2) |
0.336 | 0.627 | 0.496 | ||||||
| HN-CCI (0 vs. 1 vs. 2 vs. ≥3) | 0.802 | 0.574 | 0.098 | ||||||
| Tracheostomy (no vs. yes) | 0.187 | 0.080 | 0.271 | ||||||
| Mean daily calorie intake during CCRT |
0.005 | 0.167 (0.016~0.257) |
0.001 | <0.001 * | 0.148 (0.044~0.250) | 0.006 * | 0.914 | ||
| Treatment-associated factors | |||||||||
| CCRT Regimen | |||||||||
| RT dose | 0.874 | 0.792 | 0.862 | ||||||
| RT fractions | 0.567 | 0.533 | 0.806 | ||||||
| RT duration (days) | 0.474 | 0.670 | 0.855 | ||||||
| Cisplatin dose | 0.534 | 0.173 | 0.658 | ||||||
| Grade ¾ toxicity | |||||||||
| Dermatitis (ref: yes) | 0.262 | 0.111 | 0.985 | ||||||
| Pharyngitis (ref: yes) | 0.706 | 0.950 | 0.247 | ||||||
| Infection (ref: yes) | 0.959 | 0.752 | 0.038 * | ||||||
| Mucositis (ref: yes) | 0.017 * | 2.538 (1.038~4.038) |
0.001 | 0.796 | 0.628 | ||||
| Emesis (ref: yes) | 0.706 | 0.354 | 0.495 | ||||||
| Anemia (ref: yes) | 0.759 | 0.040 * | 0.158 | ||||||
| Neutropenia (ref: yes) | 0.958 | 0.251 | 0.178 | ||||||
| Thrombocytopenia (ref: yes) | 0.565 | 0.186 | 0.976 | ||||||
| NIMs before CCRT | |||||||||
| PG-SGA (well: moderate: severe) | 0.133 | 0.473 | 0.706 | ||||||
| BMI | <0.001 * | −0.367 (−0.556~−0.177) |
0.001 | 0.030 * | 0.914 | ||||
| BW | <0.001 * | 0.017 * | 0544 | ||||||
| Hb | 0.740 | 0.304 | 0.958 | ||||||
| WBC | 0.150 | 0.689 | 0.229 | ||||||
| Platelet | 0.098 | 0.469 | 0.171 | ||||||
| TLC | 0.290 | 0.897 | 0.040 * | −0.025 (−0.040~−0.009) |
0.029 * | ||||
| Albumin | 0.022 * | 0.464 | 0.380 | ||||||
| CRP | 0.101 | 0.624 | 0.907 | ||||||
* represents a significant p-value. Abbreviations: CCRT, concurrent chemoradiotherapy; HN-CCI, Charlson Comorbidity Index; ECOG, Eastern Cooperative Oncology Group; PG-SGA, patient-generated subjective global assessment; RT, radiotherapy; NIMs, nutritional/inflammatory markers; BW, body weight; BMI, body mass index; Hb, hemoglobin; WBC, white blood cell; TLC, total lymphocyte count; CRP, C-reactive protein; LBM, lean body mass; TFM, total fat mass; BMC, bone mineral content. Δ indicates a value obtained by subtracting the pre-CCRT value from the post-CCRT value.