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. 2021 Sep 12;26(18):5529. doi: 10.3390/molecules26185529

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Rutin significantly induces mitochondrial-mediated apoptosis in cervical cancer cells. (A) Rutin-induced mitochondrial membrane potential (MMP) disruption in cervical cancer SiHa cells analyzed by staining with fluorescent dye Rh123 and (B) MitoTracker Red. (C) Rutin induces the release of cytochrome c in cervical cancer SiHa cells assessed by a human cytochrome c enzyme-linked immunosorbent assay kit. The results are represented as mean ± SEM of three independent experiments (* p < 0.01, ** p < 0.001 compared with control group).