Table 1.

Summary of CAF-targeted therapies.

Pathway	Compound	Targets	Cancer	Mechanism	Ref.
MMP9	GS-5745	MMP9	Colorectal	Inhibition of tumor growth and metastasis	[123]
Hedgehog		Smo	Pancreatic	Decrease in fibroblast accumulation and easier drug delivery	[124]
		Shh/Gli pathway	Breast	Reduction in cell migration and invasion	[125]
TGF-β	LY2109761	TGF-β receptor1	Hepatic	Reduction in the stromal compartment	[126]
	Galunisertib		Ovarian	Prevention of CAF activation and reduction in proliferation and invasion	[127]
	Realaxin-2	Smad2 pathway	Pancreatic	Decrease in tumor growth and increase in sensitivity of gemcitabine	[128]
	Artesiminin	TGF-β	Breast	Inactivation of CAFs and inhibition of cancer growth and metastasis	[129]
Reprograming	ATRA	HSP47	Pancreatic	Reprograming of PSCs, reduction in Wnt signaling, and modulation of proliferation, apoptosis, and invasion	[130]
	Nano-system (ATRA+ anti HSP47)			Reprograming of PSCs, reduction in ECM production, and increase in chemotherapeutic effects	[131]
	VDR ligand			Induction of quiescent PSCs from activated PSCs	[132]