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Immunohistochemistry in systemic ALK- ALCL. (A) CD30 (120 kDa glycoprotein) is strongly and diffusely positive in the tumor cells with a membranous and Golgi dot-like pattern. The Golgi labelling corresponds to the location of the CD30 protein precursor of 90 kDa. (B) CD30 highlights the sinusoidal distribution in a partially involved lymph node. (C) The ALK immunostain is negative. (D) Characteristic co-expression of CD4 (left) and cytotoxic markers, such as granzyme B (right).
