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. 2021 Sep 17;13(18):4667. doi: 10.3390/cancers13184667

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Differential diagnosis of systemic ALK- ALCL. (A) The morphology of ALK+ ALCL is indistinguishable from that of ALK- ALCL; however, the ALK immunostain is positive (inset). (B) Peripheral T-cell lymphoma, not otherwise specified, with large cells. The tumor cells have a paracortical distribution but are monotonous and not as pleomorphic as seen in ALCL. In addition, CD30 is only focally positive (inset). (C) Classic Hodgkin lymphoma. Reed-Sternberg cells are positive for CD30 (red) and dim PAX5 (inset, CD30/PAX5 double immunolabeling). (D) Anaplastic large B-cell lymphoma. The tumor cells are strongly positive for PAX5 (inset).