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. 2021 Sep 17;13(18):4667. doi: 10.3390/cancers13184667

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Differential diagnosis of systemic ALK- ALCL. (A) Histiocytic sarcoma resembling ALCL. The tumor cells are positive for CD163 (inset), and negative for CD30 or T-cell markers (not shown in Figure). (B) Embryonal carcinoma with solid and pseudoglandular patterns. Note the deeply basophilic cytoplasm, anaplastic features, and abundant apoptosis. The tumor is strongly positive for CD30 (inset), cytokeratin, and OCT3/4 (not shown in Figure). (C) Epithelioid sarcoma mimicking ALCL. The tumor is positive for cytokeratin (inset) and ERG, while negative for INI1 (not shown in Figure). (D) Epithelioid melanoma metastatic to a lymph node. The neoplastic cells are positive for Melan-A (inset).