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. 2021 Sep 17;13(18):4667. doi: 10.3390/cancers13184667

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Putative cell(s) of origin of systemic ALCL. The methylation pattern of ALCL is similar to that of immature T-cells/thymocytes at certain stages of differentiation. ALK- ALCL has a methylation profile similar to a double-positive (CD4+/CD8+) thymic precursor. Nevertheless, multiple other subtypes of mature T-cells might also represent a potential precursor of this lymphoma (dashed arrows). ALK+ ALCL may also derive from similar mature T-cell subtypes as ALK- ALCL but this is not illustrated for simplicity.