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Genetic abnormalities in pc-ALCL.
| Genetic Alteration | Frequency |
|---|---|
| Clonal T-cell receptor gamma genes | ~90% |
| ALK and t(2;5) translocation | Absent in 80–90% |
| Gains of 7q31, 17q, and 21 Losses of 3p, 6q16–6q21, 6q27, 8p, and 13q34 |
~50% |
| Rearrangement of the DUSP22-IRF4 locus on 6p25.3 | ~25% Detection of 6p25.3 rearrangement by fluorescence in situ hybridization is highly specific for pc-ALCL (specificity of 99%) |
