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. 2021 Aug 25;10(9):1338. doi: 10.3390/antiox10091338

Figure 3.

Figure 3

Systemic administration of KYC ameliorates plaque psoriasis in mice. Mice were shaved on the back two days before psoriasis induction. At the experiment start, mice were systemically IP administered KYC or PBS alone daily for six days and at the same time, IMQ cream was applied daily for five days. (A) Experimental timeline and treatment regimen is shown. (B) Average daily PASI scores for each condition are shown. (C) AUC from the entire disease course was calculated from the individual daily scores. (D) Peak psoriasis incidence on day 4 is shown. (E) Representative skin images were recorded at peak psoriasis (day 4). Cream control = white circles; IMQ psoriasis = black circles; IMQ + 0.3 mg/kg KYC = gray triangles; IMQ + 3 mg/kg KYC = gray squares. Each data point represents one mouse. Data shown are the mean and SEM (BD). Data include two replicate experiments containing 3–4 mice per group (AD). * p ≤ 0.05.