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. 2021 Aug 25;10(9):1338. doi: 10.3390/antiox10091338

Figure 4.

Figure 4

Topical administration of KYC in cream ameliorates plaque psoriasis in mice. Mice were shaved on the back two days before psoriasis induction. At the experiment start, IMQ cream was applied daily for five days in the morning (AM). KYC in cream was administered at least eight hours after IMQ once signs of psoriasis began. Mouse PASI scores were assessed prior to IMQ cream application (AM) and prior to KYC cream treatment (PM); shown are the average scores. (A) Experimental timeline and treatment regimen. (B) Composite daily PASI scores averaged between AM and PM treatments are shown. (C) AUC from the entire disease course was calculated from the daily scores. (D) Peak psoriasis incidence on Day 3 (AM + PM) was isolated for comparing treatment groups. (E) Representative skin images were recorded at peak psoriasis (Day 3). Cream control = white circles; IMQ psoriasis = black circles; IMQ + 0.3 mg/kg KYC = gray triangles; IMQ + 3 mg/kg KYC = gray squares. Each data point represents one mouse. Data shown are the mean and SEM (B–D). Data include two replicate experiments containing 3–4 mice per group. * p ≤ 0.05.