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. 2021 Sep 7;10(9):1426. doi: 10.3390/antiox10091426

Figure 2.

Figure 2

Effects of treatment with antibiotics on ecological indices and microbial phyla of in the gut from imiquimod (IMQ) mice. (A) Linear discriminant analysis Effect Size (LEfSe) recognized significant differences in bacterial taxa enriched in each cohort at LDA Score > 3.5, and Kruskal–Wallis test amongst classes and Wilcoxon test amongst subclasses with threshold 0.05 (red bars Control enriched, green bars IMQ enriched). (B) Ecological parameters, (C) Proportion of bacterial phyla, and (D) Proportion of SCFAs-producing-bacteria in the microbiota from control (CTR), IMQ and IMQ-groups treated with Vancomycin (VANCO) or our cocktail of antibiotics (MIX). Data is represented as means ± SEM. One-way ANOVA and Tukey post hoc test (ecological parameters, and phyla proportion), two-way ANOVA with the Tukey’s multiple comparison test (SCFA-producing bacteria proportion). * p < 0.05 compared to CTR group; * p < 0.05, † p < 0.01, ‡ p < 0.001 compared to the untreated IMQ group.