Figure 1.

Interests and prerogatives of Non-Human Primates (NHP) models for HIV science. NHP models can be designed according to the question addressed, choosing primates from different species or origins that can be infected with different viruses. NHP models provide a means to study samples and tissues that are challenging to obtain and study in humans, as well as the possibility to access baseline values of the studied parameters and to study the earliest stages of infection after inoculation. Distinct times and routes of administration can be tested and analytical treatment interruptions (ATI) can be easily performed and monitored.