Table 1.

Main predisposing factors for Cranial cruciate ligament (CrCL) rupture in dogs in comparison with humans.

Predisposing Factors	Dog	Man/Woman
Breed and body weight	Large breeds and/or overweight dogs	Obesity
Age	2–10 years old	15–45 years old
Sex	Neutered males and spayed females	Females > Males 1
Genetics	SNP affecting genes responsible for strength and structure of CrCL	Familiar predisposition with mutations in collagen genes
Stifle deformation	Low Intercondylar notch High Tibial plateau inclination Hyperextended position of the pelvic limbs Genu varum	Low Intercondylar notch High Tibial plateau inclination Valgus knee conformation

¹ Mostly in athletes.