Table 1.

Possible antitumor mechanisms of splicing modulators

Effect	Target	Molecules	References
Cell cycle inhibition through dominant negative p27*	SF3B1	SSA	[27, 31, 73]
Changing cellular signaling and triggering cellular stress response	SF3B1	SSA	[27, 55]
Synthetic lethality in combination with SF3B1 mutations	SF3B1	H3B-8800	[76]
Changing alternative splicing of tumor-related genes, favoring tumor suppressive isoforms	SF3B1, RBM39	SSA, Indisulam, CQS, tasisulam	[74, 83, 103, 104]
Triggering antiviral response	SF3B1	H3B-8800, sudemycin D6	[70]
Generating neo-immunogens	Spliceosome	Isoginkgetin	[90, 91, 94]
Changing lncRNA behavior	SF3B1	SSA	[60]
Slowing RNA polymerase II	SF3B1	SSA	[56]
Targeting splicing factor for degradation	RBM39	Indisulam, CQS, tasisulam, E7820	[103, 104]