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. 2021 Apr 21;66(10):1009–1018. doi: 10.1038/s10038-021-00922-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Pedigree and audiograms for affected family members. a Pedigree drawing of family 4743. Squares represent males and circles females. Solid symbols signify that the individual presents with Wolfram-like syndrome and clear symbols are unaffected family members. A DNA sample from affected family member V:3 underwent exome sequencing. For each family member with an available DNA sample the genotypes are displayed for the p.(Asn1097Lys) variant. b Pure-tone audiograms of hearing-impaired family members V:1, V:3, and V:4, each illustrating bilateral HI