Table 1.
Phenotypic changes in viruses, with replacement mutations, at receptor critical sites.
| Polymorphisms at Receptor Critical Sites | MLV or ERV | Phenotype | Reference |
|---|---|---|---|
| S76Δ,S77Δ | MoMLV | Reduces infection of M. dunni cells | [52] |
| S84A | F-S MLV | Induces syncytia in M. dunni, infects hamster cells | [51] |
| Cas/Frg E-ERVs | Unknown | ||
| S82F 1 | Mo-Spl574 | Induces syncytia in M. dunni, restricted in other mouse cells | [53] |
| S82F, E114G 1 | Spl574-E114G | Correction of host range restriction of Spl574 | [54] |
| W102G | TR1.3 (FrMLV) | Syncytia formation in SC-1 cells, neurologic disease | [55] |
| E116G, W129K | PVC-211 (FrMLV) | Enhanced ability to infect hamster cells | [56] |
1 Numbering in MoMLV variants reflects the two codon upstream deletion.