Table 3.

Live-attenuated vaccines against ZIKV infection.

Vaccine’s Name or Component	Immunogenicity in the Induction of Immune Responses	Animal Model	Vaccine Doses	Administration Route	Virus Challenged	Ref.
ZIKV-3′ UTR-10-LAV	Showed complete protection from viremia and induced a saturated neutralizing antibody response	A129 mice	Single dose	s.c.	Cambodian strain FSS13025 and Puerto Rico strain PRVABC59	[34]
ZIKV-3′ UTR-20-LAV	Induced strong immune responses and protected ZIKV-induced damage to testes in mice; induced sterilizing immunity in NHPs	A129 mice and rhesus macaques	Single dose	s.c.	Cambodian strain FSS13025 and Puerto Rico strain PRVABC59	[35]
ZIKV-NS1-LAV (NS1)	Markedly diminished viral RNA levels in maternal, placental, and fetal tissues, which resulted in protection against placental damage and fetal death	A129 mice andrhesus macaques	Single dose	s.c.	Puerto Rico strain PRVABC59	[36]
LAV (with 9-amino-acid deletion in the C protein)	Not only elicited protective immunity that completely prevented viremia, morbidity and mortality, but also fully prevented infection of pregnant mice and maternal-to-fetal transmission	A129 mice	Single dose	s.c.	Puerto Rico strain PRVABC59	[37]

Note: s.c., subcutaneous injection.