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Investigating vaccine immunogenicity in rhesus macaque monkeys. (a) Schedule of mRNA-LNP injection into rhesus monkeys and sera collection. ELISA results showing comparison between serum level of anti-Spike RBD (neutralizing) antibodies in monkeys that received mRNA-LNP vaccine and the control group at days 28 (b), and 56 (c) after the 1st injection. (d) Reciprocal endpoint titer of monkey’s sera obtained by ELISA method. * p < 0.05, **** p < 0.0001.
