Figure 3.

Alignment of the VP4 antigenic epitopes of the divergent study strain, UFS-NGS-MRC-DPRU4749 that is highlighted in bold, along with global P[8] strains belonging to the already defined four different P[8] lineages, in relation to Rotarix^®. Antigenic epitopes are divided into two subunits: VP8* (8-1 to 8-4) and VP5* (5-1 to 5-5). The bold black dots (•) indicate amino acid changes in the residues that have been shown to escape neutralisation with monoclonal antibodies. The normal dots (.) represent conserved amino acids relative to Rotarix^®.