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Viral RNA packaging influences viral evolution. (a) HIV-1 virions contain two copies of the genome. After co-infection, up to 50% of progeny co-package different genomes. Template switching during reverse transcription produce cDNA that is a chimera of the two genomes; (b) Influenza A virions contain eight different vRNA segments. After co-infection, reassortant progeny virions are produced containing a mixture of segments from each parental virus.
