The binding of HIV and HIV-C to DCs is differentially affected by the P80 natural essence. HIV-1 binding to DCs was not significantly changed by pre-incubation of cells using 0.5% and 1% P80 natural essence, while HIV-C binding was significantly decreased in these concentrations. At P80 concentrations above 2.5%, a highly significant reduction in HIV and HIV-C binding to DCs was detected (HIV, light grey bars; HIV-C, dark grey bars). Uninfected iDCs were used as negative controls. Data were obtained in three independent experiments and a summary of all experiments is illustrated. Statistical analyses were done using GraphPad Prism software and one-way ANOVA with Dunnett’s post-test. * p < 0.05, ** p <0.01, *** p < 0.001, **** p < 0.0001.