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. 2021 Aug 31;9(9):976. doi: 10.3390/vaccines9090976

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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P80 natural essence boosts maturation and co-stimulatory capacity of HIV- and HIV-C-exposed DCs. HIV-loaded DCs illustrate significantly lower CD86 expression compared to HIV-C-exposed DCs (HIV vs. HIV-C). Pre-incubation of DCs with 1% P80 natural essence boosts the co-stimulatory capacity of HIV- (left) and HIV-C-(right) loaded DCs (1% P80 pre_HIV, 1% P80 pre_HIV-C), while in P80-incubated DCs this effect was not observable (1% P80 alone). The upper panel shows a summary of 4 independent donors, the lower one representative donor and the gating strategy. Dead cells were excluded by live/dead staining and activated DCs were gated as CD11chigh/CD86high population. Statistical significance was calculated with GraphPad Prism software and one-way ANOVA with Dunnett’s post-test. ** p < 0.01, **** p < 0.0001. UI, uninfected.

P80 natural essence boosts maturation and co-stimulatory capacity of HIV- and HIV-C-exposed DCs. HIV-loaded DCs illustrate significantly lower CD86 expression compared to HIV-C-exposed DCs (HIV vs. HIV-C). Pre-incubation of DCs with 1% P80 natural essence boosts the co-stimulatory capacity of HIV- (left) and HIV-C-(right) loaded DCs (1% P80 pre_HIV, 1% P80 pre_HIV-C), while in P80-incubated DCs this effect was not observable (1% P80 alone). The upper panel shows a summary of 4 independent donors, the lower one representative donor and the gating strategy. Dead cells were excluded by live/dead staining and activated DCs were gated as CD11chigh/CD86high population. Statistical significance was calculated with GraphPad Prism software and one-way ANOVA with Dunnett’s post-test. ** p < 0.01, **** p < 0.0001. UI, uninfected.