Table 2.
Pooled sensitivity and specificity for different Human Papillomavirus (HPV) detection methods in formalin-fixed paraffin-embedded oropharyngeal cancer tissue.
| Number of Studies Included in Meta-Analysis | References: | Sensitivity (95% CI) | Specificity (95% CI) | |
|---|---|---|---|---|
| RNA ISH | 5 | p16 IHC: 3 studies DNA PCR: 2 studies |
93.1 (87.4–96.4) | 91.9 (78.8–97.2) |
| DNA ISH | 4 | p16 IHC: 2 studies DNA PCR: 3 studies |
81.1 (71.9–87.8) | 94.9 (79.1–98.9) |
| DNA PCR | 5 | p16 IHC: 3 studies RNA: 2 studies |
90.4 (81.4–95.3) | 81.1 (71.9–87.8) |
| p16 IHC | 4 | RNA: 2 studies DNA PCR: 2 studies |
83.3 (69.0–91.8) | 93.5 (88.4–96.5) |
Abbreviation: Immunohistochemistry (IHC); In situ hybridization (ISH); Polymerase chain reaction (PCR); 95% confidence intervals (95% CI).