Table 2.
Rates of in-hospital adverse events from 2010 to 2017.
| Year | 2010 | 2011 | 2012 | 2013 | 2014 | 2015 | 2016 | 2017 | P value |
|---|---|---|---|---|---|---|---|---|---|
| Total patients, N | 2133 | 2545 | 2145 | 1247 | 1520 | 969 | 2159 | 1339 | |
| N (%) | |||||||||
| Any adverse event (AE) | 105 (4.92) | 121 (4.75) | 78 (3.64) | 28 (2.25) | 40 (2.63) | 20 (2.06) | 44 (2.04) | 33 (2.46) | <.0001 |
| Mortality | 1 (0.05) | 7 (0.28) | 1 (0.05) | 2 (0.16) | 1 (0.07) | 0 (0.00) | 6 (0.28) | 2 (0.15) | .5269 |
| Return to operating room | 3 (0.14) | 3 (0.12) | 2 (0.09) | 0 (0.00) | 0 (0.00) | 1 (0.10) | 2 (0.09) | 2 (0.15) | .7649 |
| AEs associated with hypoglycemic agents | 21 (0.98) | 18 (0.71) | 9 (0.42) | 2 (0.16) | 5 (0.33) | 4 (0.41) | 5 (0.23) | 1 (0.07) | <.0001 |
| AEs associated with intravenous heparin | 1 (0.05) | 1 (0.04) | 2 (0.09) | 0 (0.00) | 1 (0.07) | 0 (0.00) | 0 (0.00) | 0 (0.00) | .2096 |
| AEs associated with low-molecular-weight heparin and factor Xa inhibitor | 36 (1.69) | 57 (2.24) | 32 (1.49) | 15 (1.20) | 13 (0.86) | 2 (0.21) | 3 (0.14) | 1 (0.07) | <.0001 |
| AEs associated with warfarin | 18 (0.84) | 27 (1.06) | 13 (0.61) | 8 (0.64) | 2 (0.13) | 0 (0.00) | 1 (0.05) | 0 (0.00) | <.0001 |
| Catheter-associated urinary tract infections | 23 (1.08) | 29 (1.14) | 15 (0.7) | 9 (0.72) | 6 (0.39) | 4 (0.41) | 2 (0.09) | 2 (0.15) | <.0001 |
| Pressure ulcers | 18 (0.84) | 23 (0.90) | 19 (0.89) | 6 (0.48) | 4 (0.26) | 2 (0.21) | 3 (0.14) | 2 (0.15) | <.0001 |
| Falls | 17 (0.80) | 29 (1.14) | 21 (0.98) | 15 (1.20) | 19 (1.25) | 3 (0.31) | 17 (0.79) | 5 (0.37) | .0628 |
| Cardiac events | 2 (0.09) | 6 (0.24) | 4 (0.19) | 1 (0.08) | 3 (0.20) | 0 (0.00) | 4 (0.19) | 4 (0.30) | .5915 |
| Pneumonia | 10 (0.47) | 11 (0.43) | 8 (0.37) | 1 (0.08) | 7 (0.46) | 1 (0.10) | 5 (0.23) | 3 (0.22) | .0644 |
| Venous thromboembolic events | 6 (0.28) | 9 (0.35) | 10 (0.47) | 4 (0.32) | 3 (0.20) | 2 (0.21) | 3 (0.14) | 1 (0.07) | .0351 |
| Deep infection | 1 (0.05) | 1 (0.04) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 2 (0.09) | 0 (0.00) | .9104 |
| Wound dehiscence | 1 (0.05) | 3 (0.12) | 1 (0.05) | 0 (0.00) | 1 (0.07) | 0 (0.00) | 1 (0.05) | 1 (0.07) | .6577 |
| Hematoma | 6 (0.28) | 4 (0.16) | 6 (0.28) | 1 (0.08) | 4 (0.26) | 1 (0.1) | 3 (0.14) | 2 (0.15) | .3178 |
| Major bleeding/hematoma | 59 (2.77) | 64 (2.51) | 35 (1.63) | 14 (1.12) | 19 (1.25) | 5 (0.52) | 19 (0.88) | 13 (0.97) | <.0001 |
| Cardiovascular AEs | 6 (0.28) | 7 (0.28) | 7 (0.33) | 2 (0.16) | 0 (0.00) | 1 (0.10) | 3 (0.14) | 4 (0.30) | .2268 |
| Revision surgery during index hospitalization | 0 (0.00) | 1 (0.04) | 0 (0.00) | 0 (0.00) | 1 (0.07) | 6 (0.62) | 7 (0.32) | 7 (0.52) | <.0001 |